Refutation—davidbdale

Help if you need it.


The material I gathered to prepare for this Argument I have moved to a special section of my White Paper to illustrate the value of collecting all my sources in the WP, the repository of all things useful to my Research Position Paper.


What I Refute

My Refutation Argument examines the primary claims of the hypothesis I defended in my Definition Argument, that because polio is fundamentally unlike smallpox—which was eradicated in the 1960s—the differences make it nearly impossible to eradicate polio, ever.

dog-awake

The World Health Organization (WHO) and in particular its Global Polio Eradication Initiative (GPEI) have maintained for decades now that the eradication of smallpox strongly argues in favor of the eradicability of polio. They use that analogy to raise $1 billion a year for their efforts. I entirely applaud their audacious enterprise, but I question the quality of their analogy. In 1000 words, I argue that smallpox and polio ARE NOT similar enough for the comparison to hold.

If it sounds ridiculous to devote 1000 words to the OPPOSITE of my own hypothesis, you’re misunderstanding a crucial element of good argument. To persuade skeptics to your point of view, you must address and refute the strongest counterarguments. Ignoring them is fatal. Readers will merely humor you if you try to skirt the best refutations and never change their minds.

  1. My post will be about 1000 words before the References section.
  2. It will use in-text citations WITHOUT parentheses.
    • Please follow this model in your posts as well.
  3. It will use an APA-style References section
    • APA is the new style choice of the Writing Arts Department
    • I made mine for free using BibMe.com
  4. It will PRESENT but also REFUTE strong arguments against my hypothesis. It’s not AN OPPOSITION ARGUMENT, but a CONFIRMATION ARGUMENT that identifies objections to the hypothesis before re-affirming it.
  5. It’s a first draft, so it will embarrass me until I revise it.
  6. Once I revise it, it will be a second draft, still embarrassing but less so.
  7. Questions? Use the Reply field below this post.

Draft Rebuttal

The eradication of smallpox from planet Earth in 1980 by a worldwide immunization campaign raised unrealistic hopes that other diseases could be similarly vanquished. The exuberance of health professionals who set their sights immediately on polio, malaria, and cholera was understandable, but dangerous. If polio were identical to smallpox, the same techniques might suffice to eradicate it next. But if polio is fundamentally different, then the argument from analogy to smallpox fails, and efforts to eradicate polio, based on the argument that “it’s been done before,” could more than just fail; they could backfire catastrophically. The cost of the attempt is enormous, and the risk of failure is very high, so let’s examine the similarities between smallpox and polio and see if they augur success.

Several factors are considered essential to any eradication effort. Christopher Whitty, professor of public and international health at the London School of Hygiene and Tropical Medicine, identifies three. Others may count differently, but if polio and smallpox are sufficiently different in any category essential to eradication to void the comparison, the “did it before” argument will fail. In his Millroy Lecture “Eradication of Disease: Hype, Hope, Reality,” he names as the first pre-requisite: “effective interventions that alone or in combination can interrupt transmission of infection or at least take it well below R0 = 1 in all epidemiological settings.”

As Whitty explains it, R0 = 1 represents the situation where one infected person passes on the disease to just one other person who in turn does the same so that the disease stays stable in the population. At a minimum, then, interventions must exist that can prevent rapid spreading during an outbreak. In the best case, when the R0 can be forced below 1, local elimination and potential eradication can be achieved. For much of the world, local elimination has already been accomplished. In all but a few countries, no new cases of polio have been detected in decades. As described by Ganapathiraju, Morssink, and Plumb in “Endgame for Polio Eradication?“:

in 1955, polio paralysed and killed up to 500,000 people annually worldwide. Salk’s inactivated polio vaccine (IPV) reduced polio transmission in the USA from 20,000 cases per year in the 1950s to around 1000 cases by the 1960s. [Since then,] polio worldwide has decreased from an estimated 350,000 cases in 1988 to just 416 cases in 2013.

Such remarkable success—a 99.9% reduction in diagnosed cases in 30 years!—continues to encourage eradication advocates, including the Bill Gates Foundation, the World Health Organization, and the Global Polio Eradication Initiative (GPEI) that total triumph is inevitable, if not imminent. In fact, seemingly every year, when it solicits funding for its continuing effort, the GPEI announces a “game-changing” or “breakthrough” technology that will once and for all achieve the ultimate victory.

But that victory has so far proved elusive, perhaps because of fundamental differences between smallpox and polio. Again according to Whitty, to be eradicable, “the disease has to be easy to diagnose, preferably with minimal complex laboratory facilities.” But whereas schoolchildren were able to detect the last cases of smallpox among their classmates by casual external observations alone, they would be no help detecting polio, which can persist completely unnoticed in human hosts for decades without causing symptoms.

Fortunately for polio eradication advocates, Whitty’s third essential factor presents no challenge. Polio exists either in human hosts or not at all. There is no significant “wild animal reservoir” for the disease to harbor in between human hosts. But the final ironic difference between the smallpox and polio viruses is that polio uses humans as a sort of “animal reservoir,” and while it persists in unwitting human hosts, often subjected to repeated rounds of immunization efforts, it mutates, emerging as something no longer “wild,” but transformed into a “vaccine-derived virus.”

This last and perhaps most significant difference between smallpox and polio may be the distinction that finally tips public sentiment against spending staggeringly large sums to eliminate a disease that presently afflicts so few. As reported in “The Art of Eradicating Polio” by Leslie Roberts, a Nigerian boy recently voiced the bewilderment of his country in a conversation with Muhammad Ali Pate, Nigeria’s Minister of State for Health. “Why do they bring only polio vaccine when we get no help with all our other problems? And are you going to force us to take it?” he asked. His question illustrates a reluctance that is increasingly difficult to surmount among populations whose children die by the thousands from diarrhea.

The longer the final stage of eradication drags on the more challenges it faces. Despite impressive successes, and there have been many, setbacks seem maddeningly inevitable. Alwan and Maher report, in 2016, in “Closer to a Polio-Free Eastern Mediterranean Region” that

WHO alone has more than doubled the size of the teams working on polio in the two countries since the start of 2014, and now has nearly 2500 technical and operational experts in the field . . . only 30 cases of polio have been recorded by Pakistan (18 cases) and Afghanistan (12 cases) combined so far in 2016 – a far cry from the 334 cases recorded by these countries in 2014.

Yet, according to Svea Closser’s “We Can’t Give Up Now: Global Health Optimism,” after worldwide spending of nearly $1 billion again in 2016, the fight did not end. Neither did another billion accomplish the goal in 2017. One must ask, as many governments, private foundations, public health professionals, and that Nigerian boy already have, “How much longer can we justify spending so much of our scarce resources on a disease that most of the world has not seen in decades?”

Even success, if it’s achieved, might not be success. As Closser warns us, “When smallpox was declared eradicated, countries could decide independently whether or not to stop vaccinating. For polio, this approach could prove disastrous.” The cheaper OPV vaccines are a double-edged sword. They are favored for mass inoculations and millions of doses are delivered every year, preventing countless cases of polio. But they deploy “weakened live virus strains” that can “evolve to reacquire the ability to cause paralytic disease and to spread. Outbreaks of circulating vaccine-derived polioviruses have occurred before [in 11 countries since 2000]; more are virtually inevitable.”

It’s even possible that vaccine-derived viruses could evolve to mimic the three “wild” polio viruses we’ve taken such pains to eradicate. If that happens, according to Closser, “the gains from interrupting wild polio transmission will be lost; the entire effort will only have succeeded in replacing one set of viruses with another.”

References

Alwan, A., & Maher, C. (2016). Closer to a polio-free Eastern Mediterranean Region. Eastern Mediterranean Health Journal, 22(9), 645-646. doi:10.26719/2016.22.9.645

Closser, S. (2012). We Can’t Give Up Now. Medical Anthropology, 31(5).

Ganapathiraju, P. V., Morssink, C. B., & Plumb, J. (2015). Endgame for polio eradication? Options for overcoming social and political factors in the progress to eradicating polio. Global Public Health, 10(4), 463-473. doi:10.1080/17441692.2014.994655

Roberts, L. (2013, October). The art of eradicating polio. Science342(6154).

Whitty, C. J. (2014, August 01). Milroy Lecture: Eradication of Disease: Hype, Hope and Reality. Retrieved March 18, 2018, from http://www.clinmed.rcpjournal.org/content/14/4/419.full

Author: davidbdale

Inventor of and sole practitioner of 299-word Very Short Novels. www.davidbdale.wordpress.com

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